Leber’s hereditary optic neuropathy or LHON is a rare inherited condition that results in rapid central vision loss.1,2 Named after Theodore Leber, who first described it in 1871, LHON affects approximately 1 in 45,000 people in Europe.2,3

Symptoms in LHON usually begin with sudden, painless blurring and clouding of central vision in one eye and then both eyes.3 It results from cell dysfunction in the optic nerve that relays visual signals from the eye to the brain.3 It affects how patients can see things.3 Each eye gets worse as the blurry blind spot rapidly expands over 6-12 months.3,4 The duration in which the eyesight gets worse varies from a few months to more than two years.3,4

Click the link below for more information about LHON, including useful resources for patients, caregivers and healthcare professionals. This website provides the latest and most reliable information on symptoms, diagnosis, familial tracing and some practical sections of FAQ.



  1. Theodorou-Kanakari A, et al. Adv Ther. 2018;35:1510–18.

  2. Carelli V, et al. J Neuro-Ophthalmol. 2017;37:371–81.

  3. Carelli V, et al. Eur Ophthalmic Rev. 2019;13(Suppl 2).

  4. Yu-Wai-Man P and Chinnery PF. Leber Hereditary Optic Neuropathy. 2000.